Clinical Data Supports the Role of Ultrafiltration in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI)
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The editorial examines the role of intravenous fluid overload in contributing to CSA-AKI and challenges the notion that diuretics are always the best management approach. Specifically, the authors wrote that greater attention is needed when maintaining intravascular volume – and said ultrafiltration should be considered when patients are unresponsive to diuretics.
“We’re thrilled to have additional validation for the technology behind Aquadex® in this new publication,” said Dr.
This editorial also reinforces data published in the
“Avoiding complications like CSI-AKI in cardiac surgery is critical, and ultrafiltration has a unique application to treat fluid overload in this space, especially when treating patients with diuretic resistance,” said
Diuretics can play a key role in managing fluid overload for some patients but are also associated with mixed outcomes and even adverse events. For example, in heart failure, 40% of patients show poor diuretic response, and 68% demonstrate a suboptimal response.2,3 Furthermore, loop diuretics provide unpredictable elimination, put patients at risk of developing low potassium and magnesium levels, and can ultimately lead to diuretic resistance that causes persistent congestion with no change to sodium levels.4 Ultrafiltration, on the other hand, provides predictable removal of sodium and fluids, restores diuretic responsiveness, and offers more effective decongestion and fewer heart failure events compared to loop diuretics.4
About Nuwellis
About the Aquadex SmartFlow® System
The Aquadex SmartFlow system delivers clinically proven therapy using a simple, flexible and smart method of removing excess fluid from patients suffering from hypervolemia (fluid overload). The Aquadex SmartFlow system is indicated for temporary (up to 8 hours) or extended (longer than 8 hours in patients who require hospitalization) use in adult and pediatric patients weighing 20 kg or more whose fluid overload is unresponsive to medical management, including diuretics. All treatments must be administered by a health care provider, within an outpatient or inpatient clinical setting, under physician prescription, both having received training in extracorporeal therapies.
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1 Heart & Vascular Program,
2 Felker MG and Mentz RJ. J Am Coll Cardiol. 2012;59(24):2145-53.
3 Doering A, et al. Int J Emerg Med. 2017;10(17).
4 Costanzo MR, et al. J Am Coll Cardiol. 2017 May 16;69(19):2428-2445.
Source: Nuwellis, Inc.
