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                          September 15, 2022

       Nestor Jaramillo, Jr.
       Chief Executive Officer
       Nuwellis, Inc.
       12988 Valley View Road
       Eden Prairie, MN 55344

                                                        Re: Nuwellis, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed September 9,
2022
                                                            File No. 333-267368

       Dear Mr. Jaramillo:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Ada D.
Sarmento at 202-551-3798 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Phillip D. Torrence,
Esq.